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Homeopathic formulations of growth factors known as Cell Signal Enhancers or CSEs are a revolutionary new class of medicines that combine today's advanced molecular biotechnolgy, basic homeopathic principles and bioelectric medicine to help people achieve a greater sense of physical and mental balance. Cell Signal Enhancers were developed and patented by Dr. Barbara Brewitt, CEO and Chief Scientific Officer of Biomed Comm, Inc.^TM Dr. Brewitt developed these natural medicines for the purpose of maximizing people's health and performance without toxic side effects and at affordable prices. Cell Signal Enhancers work by stimulating the body's own defense and healing mechanisms, bringing the body back to its optimum performance level.
CSEs contain recombinant human growth hormone or growth factors in homeopathic formulations. Recent independent clinical studies have shown that Biomed Comm's^TM homeopathic hGH patented formula increases lean body mass, improves physical appearance, energy, endurance and boosts immune system functions.

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Growth Factors

Growth factors are small proteins produced within the human body that regulate cell growth, cell specialization as well as control metabolic processes. Growth factors enable cells in the immune, nervous and hormonal systems to coordinate their growth and cell functioning plus support cell regeneration. We now know that normal cell growth is controlled by feedback between growth stimulators and growth inhibitors:

Growth factors:

• regulate cell growth, division and specialization.
• coordinate immune, nervous and hormonal systems.
• enhance cell communication.
• compete with viruses for expression of the same genetic sites.

Growth factors have significant effects on DNA, RNA, protein synthesis, amino acid uptake, cell migration, cell regeneration, wound repair, collagen repair and cell division. It has been determined that growth factors in the body affect the individual cells by binding to growth-factor-specific receptors on the cell's surface. Receptor binding initiates a sequence of events inside the cell, leading to the cell nucleus where the required action takes place through its effects on DNA synthesis. The signal from a growth factor affects the cell cycle through positive and negative feedback processes, and may be involved in controlling various cell functions.
Growth factors are well known for their different regulatory roles in the body. Regulatory function differs depending on the condition and type of cell, the presence of different hormones and proteins, and any additional stress factors that may affect tissue integrity. The following descriptions of growth factors are based on known mechanisms of action and their general regulatory roles in the body. As a hormone, human growth hormone (hGH) affects specific target tissues in its role as a chemical messenger. Human growth hormone works with insulin-like growth factor (IGF1) to affect the uptake of nutrients into the cell.

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hGH (Human Growth Hormone)

A General Introduction
Human growth hormone (hGH) has been widely acclaimed over the past few decades as the body's most powerful hormone because of its significant anabolic and anti-catabolic effects on the body. As doctors and scientists work hand in hand to find ways to extend the average life span, equal attention must be devoted to improving the quality of life and developing stronger healthier bodies through non-toxic, safe and affordable medicine.
hGH, also known as the master hormone of the body, is responsible for many effects on growth, development, immunity and metabolism. Produced and secreted by the anterior pituitary gland in the brain, hGH is usually released during sleep in pulses in response to positive and negative signals from the hypothalamus. hGH exerts anabolic effects throughout the body through its co-messenger IGF1, favoring growth of tissues, bones, cartilage, muscles, skin, liver and kidney.


The bio-engineering of recombinant human growth hormone in the mid-1980s made hGH more widely available as an injectable prescription drug than in previous decades. As a result, hGH received wide public attention for its well documented benefits on physical performance, body shape, composition and immune enhancement. Specifically hGH stimulates increased lean body mass which is a significant life extender since depletion of lean body mass results in muscle weakness, organ failure and death. More than muscle size, lean body mass encompasses bone density, organ density and vitality, restoration of shrinking cells back to their normal size and restoration of intracellular and extracellular water.
The amount of human growth hormone in a healthy adult declines about 14% per decade after age 30 and is frequently non-existent by age 80. The decrease in hGH levels seen with aging may result in detrimental health consequences such as reduced skeletal muscle mass and strength, decreased bone density, increased fat, reduced energy and exercise capacity and reduced immunity.
The American Association of Clinical Endocrinology and the American College of Endocrinology suggest that hGH deficiency is an age-related event characteristically defined as a cluster of easy to recognize symptoms which include:

• Fatigue
• Increased weight and abdominal obesity
• Decreased lean body mass and decreased muscle mass
• Decreased strength
• Poor sleep
• Impaired sense of well being
• Decreased exercise capacity and physical performance
• reduced cardiac performance

Many of the characteristics associated with aging are directly related to the amount of hGH available to the body and can be impacted upon in a positive manner if the level of hGH in the body is increased. hHG and its mediator, insulin-like growth factor-1 (IGF1), may actually help treat the blueprint of aging, keeping the cells in as healthy a state as possible. A cell's ability to function depends on the genetic codes for all the proteins, hormones, and enzymes that make the cell run. Up until now, antioxidant supplements such as vitamin C and E helped us limit the damage to the DNA and bolster our immunities.
hGH and IGF1 go further and do what antioxidants cannot do. hGH and IGF1 help the DNA repair itself prior to cell division. hGH initiates the transport of amino acids and nucleic acids into the cell, including the cell membranes. IGF1 facilities the transport of nucleic acids into the nucleus of the cell where the DNA resides, giving it the raw material needed to repair damage to the DNA and initiate cell division. With many positive effects on the body, supplementation with homeopathic human growth hormone may be a significant factor in treating symptoms of human growth hormone deficiency. Homeopathic dilutions of human growth hormone promote these benefits without the adverse side effects associated with high dose forms of injectable human growth hormone.

Homeopathic hGH
Biomed Comm has completed three different types of double-blind, placebo-controlled clinical studies to evaluate the efficacy of homeopathic human growth hormone as an oral, chewable tablet. Our clinical results (which will be incorporated into our web site after publication in medical journals) suggest that homeopathic hGH provides a safe, affordable method to optimize physical and mental functioning plus improves self-perceived quality of life values.

Just some of the benefits seen after a six week program of oral homeopathic hGH therapy are:

• Increase in energy
• Increase in muscle mass without exercise
• Decrease in body fat without dieting
• Stronger immune system functions
• Improvement in sleep patterns
• Improved physical appearance
• Increase in skin softness/suppleness
• Visual Improvements
• Improved respiratory functions
• Reduction in anxiety
• Relief of headaches
• Reduced blood pressure

Homeopathic hGH is believed to work better in conjunction with homeopathic IGF1 to improve body health, strength, endurance and mental concentration.
With many positive effects on the body, supplementation with our homeopathic hGH or in combination with our homeopathic IGF1 may be a significant advance in addressing the symptoms of aging and human growth hormone deficiency.

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IGF1 (Insulin-like Growth Factor-1)

A General Introduction

Insulin-like Growth Factor-1 (IGF1) is released by many different tissues throughout the body and affects almost every cell to some degree. Major organs that synthesize IGF1 are the human placenta, heart, lung, kidney, liver, pancreas, spleen, small intestines, testes, ovaries, large intestines, brain, bone and pituitary. Humans produce approximately 10 milligrams of IGF1 per day until about 30 years old whereby production decreases with aging. IGF1 has similarities to insulin and possesses potent anabolic and cell growth effects. IGF1 is also important for its affect on development, diabetes and other chronic diseases.
IGF1 is primarily secreted by the liver in response to a signal from human growth hormone (hGH). The major target tissues affected by the IGF1 in combination with the hGH signal are muscle, cartilage, bone, liver, kidney, nerves, skin and lungs.
IGF1 is known as a 'progression' factor. IGF1 assists competent cells toward cell division and often that is all cells need for successful activation. IGF1 cooperates with PDGF to increase the cell's ability to complete DNA synthesis. IGF1 not only helps cell growth by division, but also by enhancing cell specialization. Hormonal functions such as the anabolic (constructive) activity of hGH depends on the production and presence of IGF1 to achieve positive results.

• IGF1 increases physical performance, mental performance, and physical endurance in healthy individuals.
• IGF1 communicates an anabolic signal to cells, regulating cell division and differentiation as the muscle acquires an increased need for strength or as injury to the muscle is incurred.
• IGF1 promotes the growth of muscle and bone.
• IGF1 acts within the nervous system and is critical for the growth and development of nerve cells.
• IGF1 maintains a high level of cell communication at the neuromuscular junction, where the cooperation between the nerve and muscle cells take place.

Studies show that after a one week period of strenuous exercise, blood levels of IGF1 are significantly increased due to either regenerative processes from muscle injury or higher requirements in muscles to handle the weight load.
In aging cells, there is a greater need for more IGF1 in order to move cells out of the 'resting phase' and into a growth phase of the cell cycle. A slower growth of cells during the aging process correlates with a higher requirement of IGF1 than the body supplies. The increase in cellular communication from an addition of IGF1 may bring the aging, slower cells back into the balanced state optimizing cell activity and tissue/organ performance.

Homeopathic IGF1
Homeopathic IGF1 works in many different areas of the body to facilitate and improve cellular performance. A recent independent double-blind, placebo-controlled clinical testing of homeopathic IGF1 demonstrated effectiveness in the nervous, reproductive, musculo/skeletal, and gastrointestinal systems. Specifically, homeopathic IGF1 improved energy levels and physical performance, respiratory conditions, and relieved symptoms of PMS and menopause. It also relieved muscle and bone aches and pains, joint stiffness, inflammation in the body, improved mental concentration and clarity and positively affected appetite. Increases in lean body mass also have been anecdotally reported. Homeopathic IGF1 balances weight by helping the body to achieve its ideal weight, whether that means losing weight for people too heavy, or gaining weight for people too lean.
IGF1 is believed to bring aging, resting cells back into a balanced state optimizing cell activity and tissue performance.

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PDGF (Platelet-derived Growth Factor)

A General Introduction
As we age or if we have a chronic illness increasing numbers of cells are in the resting state and have difficulty entering into an active state capable of repair. PDGF acts on resting cells to make them competent to enter the cell cycle.
Pain in the body indicates there is a wound which requires cell repair and cell regeneration. When blood clots as a result of a wound in the vascular system, the surrounding cells release various substances to facilitate the clotting and regenerative process. PDGF is one of the small proteins released. This growth factor allows unspecialized connective tissue cells, called fibroblasts, to divide and stimulate connective tissue cells and smooth muscle cells to divide at the wound site in order to repair the damaged area.
Platelets, macrophages, endothelial and smooth muscle cells from an injured area all secrete PDGF to assist in reparation, which in turn eases the pain associated with the wound. During wound healing two processes occur; first, PDGF stimulates the proliferation of fibroblasts and smooth muscle cells and second, macrophages and fibroblasts within the injured area produce more extra-cellular matrix material to close the wound.
Cells most responsive to PDGF are skin, vasculature, nervous system, immune system, smooth muscle cells (which control digestion, breathing and blood flow) and embryonic cells. As competence and progression factors, PDGF and IGF1, respectively work together to effectively move cells through the cell cycle.

Homeopathic PDGFBB
Homeopathic PDGFBB is a gentle pain relief medication effective in alleviating chronic aches and pains. Daily activity causes wear and tear on the body, which can be quickly repaired by the body's healing mechanisms. As the body ages, the recovery time gets slower and the body is not repaired as quickly, causing aches and pains. Homeopathic PDGFBB helps the body repair this wear and tear from both normal and strenuous activity, in turn reducing the aches and pains. Anecdotal evidence has also shown homeopathic PDGFBB to be effective in improving stamina, allowing people to be "on the go" and in the relief of respiratory conditions. Based on preliminary clinical tests, homeopathic PDGFBB is hypothesized to speed wound repair processes in combination with homeopathic IGF1 and homeopathic TGFb1.

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TGFb1 (Transforming Growth Factor-1)

A General Introduction
TGFb1 acts primarily as an on/off switch for cell multiplication and differentiation. TGFb1 regulates the receptors for IGF1 and PDGFBB. Individual cells behave differently in terms of cell division based on the cell type, the other proteins present and the concentration of TGFb1. Some cells up-regulate and some down-regulate DNA synthesis and/or cell division in the presence of TGF b1. Its effect on the cell depends on the status of the cell. TGFb1 helps epithelial cells (cells lining inner and outer surfaces) to specialize. When the cell is relatively unspecialized, like in tumor growth, the cell may experience an inhibitory effect, whereas if the cell is carrying out a specific role, this growth factor enhances cell activity. During inflammatory processes, TGF b1 orchestrates the healing process.
Cell proliferation activated by other growth factors or biologic effects of hormones is mediated by TGFb1. TGFb1 plays an important role in the cell division and differentiation in the areas of bone development and repair, cartilage growth and repair, blood cell development, fat cell development, and muscle cell specialization. It also is necessary for skin cell formation, and immune Tlymphocyte cell division. Thus tissue repair, immune function and regulation of inflammatory conditions all require TGF b1.

Homeopathic TGF b1
Also important in the wound healing processes, homeopathic TGF b1 assists in the relief of minor skin irritations and inflammation. Homeopathic TGFb1's anti-inflammatory properties work not only in the muscles and soft tissue, but also in the nervous system for relief of anxiety and the respiratory system for allergy relief. Similar to its function in the body, homeopathic TGFb1 may work in conjunction with homeopathic IGF1and homeopathic PDGFBB to maintain optimal cellular activity. Anecdotal evidence has shown the combination of homeopathic TGFb1, and homeopathic IGF1 to help alleviate fatigue.

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